Welcome to IOCB Boston

The first outpost of Czech science in the United States.

Our team of top international scientists strives to provide new invaluable insights into the research of nutrient sensing and growth control, neurodegenerative diseases and longevity.

Excellence. Curiosity. Compassion.

We may have already met

Our home institute, the Institute of Organic Chemistry and Biochemistry, located in Prague, Czechia, ranks among the best in Central Europe and has already left its mark in medicinal chemistry. Do any of these words ring a bell? To find out more about our work, browse our Highlights.

Viread Atripla Biktarvy Vidaza Dacogen Lu-177 DRP-104 Carbetocin Desmopressin iBodies

Our research groups

David Sabatini Lab

Nutrient sensing by mTORC1 in vitro and in vivo
Lysosomal function in physiology and disease
Nutrient transport in mitochondria
Methods of study of small molecule metabolism in vivo

David M. Sabatini, MD, PhD

Expert on mTOR pathway, a key nutrient-sensitive growth regulator and target of the anti-aging drug rapamycin. His research interests include other growth regulation processes responsible for mass accumulation of cells and organisms. Senior group leader at IOCB Boston and IOCB Prague.